Bindarit alleviates inflammation and early brain injury following experimental subarachnoid hemorrhage in rats

Bindarit is a small indazolic derivative which has shown anti-inflammatory and neuroprotective effects on multiple central nervous system (CNS) injuries. The effects of bindarit on subarachnoid hemorrhage (SAH) are not explored. This study was aimed to research the effects of bindarit on neuroinflammation and early brain injury (EBI) after experimental SAH in rats. Rats were randomly divided into sham, SAH, SAH+vehicle, and SAH+bindarit groups. Twenty-four hours after SAH, the SAH grade, neurological function, brain edema, blood brain barrier (BBB) permeability, cellular apoptosis, levels of inflammatory cytokines and microglial activation were evaluated. Results showed that administration of bindarit significantly ameliorated EBI including brain edema, BBB damage, cellular apoptosis and neurological deficits. In addition, bindarit also reduced inflammatory cytokine levels and microglial activation 24 h after SAH. In conclusion, the administration of bindarit might attenuate EBI following SAH through the downregulation of SAH-induced neuroinflammation.